The Liverpool striker is understood to have suffered meniscus damage during a training session on
Wednesday with the rest of the Uruguay squad.
Suarez, 27, is now expected to undergo an operation on Thursday, placing his participation in this summer's tournament in serious doubt.
The news will concern fans of his club Liverpool, but for England it would be a huge boost should the striker not be fit for the group stage clash with Uruguay on June 19.
Luis Suarez is set to undergo knee surgery which could see him ruled out of the World Cup, according to widespread reports.